Hello Vel_VMware,
Are they PDL and/or only showing as UUID reference (not by naa.)?
# vdq -q
# vdq -Hi
If they are PDL/gone then check the config-status of the data Objects to determine if removing them without evacuation is safe - this can be checked via cmmds-tool short scripts or via the Health check in the Web Client under 'Data'.
If it is determined safe to remove them without migrating data off or using Ensure Accessibility (e.g. all data has been rebuilt already) then you can use the esxcli remove command but make sure you are positive that the data is in an okay state before doing this as this permanently deletes any data on these disks (and responsibility for checking this lies with you alone).
Hope this helps.
Bob